个人简介

林琳，女，教授，主要从事生物医药，分子生物学，蛋白质工程方向研究。

教育经历

1981.9-1985.6   辽宁大学   环境生物学专业       本科 

1997.9-2001.6   福建农林大学   植物病理学专业   博士

2004.8-2016.3   哈佛大学医学院   医学专业       博士后

主要参与的项目

1.工业微生物高通量选育与保藏技术研发平台建设，2006H0085，主持；

2.扩展青霉碱性脂肪酶基因克隆、表达及突变体研究，B0120001，主持

3.洗涤剂配套酶制剂―碱性脂肪酶研究，96c-03-02-01，主持

4.Structural Aspects of Urokinase Receptor in Vascular Biology，RO1 5R01HL086584-03，参加

5.Thrombus formation in vivo，PO1 HL087203，参加

6.Program in blood coagulation and vascular biology，T32 5T32HL007917-14，参加

7.Protein disulfide isomerases: A new class of antithrombotic targets，1U54HL112302-01，参加

8.Thiol Isomerases in Hemostasis and Thrombosis，5R35Act HL135775，参加

9.Biomarkers and mechanisms in cancer associated thrombosis，5TU01 Act HL143365，参加

主要成果

1.Liu M*, Lin L*（co-first）, Høyer-Hansen G, Ploug M, Li H, Jiang L, Yuan C, Li J, Huang M. Crystal structure of the unoccupied murine urokinase-type plasminogen activator receptor (uPAR) reveals a tightly packed DII-DIII unit. FEBS Lett. 2019 Jun;593(11):1236-1247

2.Yunbin Jiang, Lin Lin*（co-coresponding）Shanli Chen, Longguang Jiang, Mette C. Kriegbaum, Henrik Gårdsvoll, Line V. Hansen, Jinyu Li, Michael Ploug, Yuan Cai, Mingdong Huang*. Crystal Structures of Human C4.4A Reveal the Unique Association of Ly6/uPAR/α-neurotoxin Domain。International Journal of Biological Sciences 2020; 16(6): 981-993.  

3.Lin Lin, Blocking the b'x domain of PDI interferes with its interaction with aIIbb3 and prevents thrombus formation. International Society on Thrombosis and Haemostasis (ISTH) 2017 Congress July 8 to 13, 2017, Berlin, German (oral presentation)

4.Chen, Shanli(#); Lin, Lin(#) (co first); Yuan, Cai; Gardsvoll, Henrik; Kriegbaum, Mette C.; Ploug, Michael; Huang, Mingdong.  Expression and crystallographic studies of the D1D2 domains of C4.4A, a homologous protein to the urokinase receptor Acta Crystallographica Section F-Structural Biology Communications, 2017.8, 73: 486~490 

5.Lin Lin, Srila Gopal, Anish Sharda, Freda Passam, Sheryl R. Bowley, Jack Stopa, Guangpu Xue, Cai Yuan, Barbara C. Furie, Robert Flaumenhaft, Mingdong Huang, Bruce Furie，Quercetin-3-rutinoside inhibits protein disulfide isomerase by binding to its b'x domain. J. Biol. Chem. 2015 290: 23543-23552