个人简介
卢余盛，男，7003全讯白菜网址，副教授
邮箱：lu_yu_sheng@126.com
研究方向：肿瘤转移机制和肿瘤转移预防药物研发，生物医学检测
教育经历
2006.9-2010.6 黑龙江八一农垦大学 生物技术专业 本科
2011.9-2016.6 福州大学 生物化工专业 博士
2016.9-2018.11 福州大学 博士后
2018.3-2018.6 中国医药大学（中国台湾） 访问学者
主要参与的项目
1. 国家自然科学基金青年项目，基于一氧化氮通过改善血液微环境干预肿瘤血路转移的分子机制研究，81703555，主持。
2. 中国博士后科学基金面上一等资助，斯诺普利改善血液微环境调控肿瘤血路转移的机制研究，2017M620268，主持。
3. 福建省海峡博士后交流资助基金，低氧诱导代谢重组调控肿瘤细胞存活和转移的细胞分子机制研究，02510515，主持。
4. 福建省自然科学基金面上项目，循环肿瘤细胞粘附于血管内膜激活TRIM22促进肿瘤转移的分子机制研究，2020J0185，主持。
5. 福州市科技计划项目，一氧化氮促进蛋白质组巯亚硝基化修饰抑制肿瘤转移的分子机制研究，2021-S-094，主持。
6. 福州海洋研究院产学研科技项目，基于鲎重组C因子的高灵敏内毒素检测技术和产品的研发，2021F08，主持。
7. 企业横向项目，一种适用于外周血中循环肿瘤细胞扩增培养的技术开发，主持。
主要成果
1. Yu Zhou, Fan Chen, Xiaodong Xie, Huifang Nie, Shu Lian, Chunlian Zhong, Chengbin Fu, Weiyu Shen, Bifei Li, Yusheng Lu*, Lee Jia*.Tumor-derived Exosome Promotes Metastasis via Altering its Phenotype and Inclusions. Journal of Cancer. 2021, 12: 4240-4246. doi:10.7150/jca.48043.
2. Zhong, CL.#, Yang, JY.#, Lu,YS.#, Xie, HZ.#, Zai, S., Zhang, C., Luo, ZY., Chen, X., Fang, X., Jia*L. Achyranthes bidentata polysaccharide can safely prevent NSCLC metastasis via targeting EGFR and EMT. Signal Transduc Targeted Therapy. 2020；5:178.
3. Yusheng Lu, Shu Lian, Yuying Ye, Ting Yu, Haiyan Liang, Yunlong Cheng, Jingjing Xie, Yewei Zhu, Xiaodong Xie, Suhong Yu, Yu Gao, Lee Jia*. S-nitrosocaptopril prevents cancer metastasis by creating the hostile bloodstream environment against circulating tumor cells. Pharmacological Research. 2019. 139: 535-549.
4. Yusheng Lu, Shu Lian, Yunlong Cheng, Yuying Ye, Xiaodong Xie, Chengbin Fu, Chen Zhang, Yewei Zhu, M. Iqbal Parker, Lee Jia*. Circulation patterns and seed-soil compatibility factors cooperate to cause cancer organ-specific metastasis. Experimental Cell Research. 2019. 375: 62-72.
5. Shu Lian, Xiaodong Xie, Yusheng Lu*, Lee Jia*. Checkpoint CD47 Function On Tumor Metastasis And Immune Therapy. OncoTargets and Therapy. 2019. 12:9105-9114.
6. Yunlong Cheng#, Yusheng Lu#, Doudou Zhang, Shu Lian, Haiyan Liang, Yuying Ye, Ruizhi Xie, Shuhui Li, Jiahang Chen, Xuhui Xue, Jingjing Xie, Lee Jia*. Metastatic cancer cells compensate for low energy supplies in hostile microenvironments with bioenergetic adaptation and metabolic reprogramming. International Journal of Oncology. 2018. 53: 2590-2604.
7. Shu Lian#, Yusheng Lu#, Yunlong Cheng, Ting Yu, Xiaodong Xie, Haiyan Liang, Yuying Ye, Lee Jia*. S-nitrosocaptopril interrupts adhesion of cancer cells to vascular endothelium by suppressing cell adhesion molecules via inhibition of the NF-кB and JAK/STAT signal pathways in endothelial cells. European Journal of Pharmacology. 2016; 791:62-71.
8. Yusheng Lu, Haiyan Liang, Ting Yu, Jingjing Xie, Shuming Chen, Haiyan Dong, Patrick J. Sinko, Shu Lian, Jianguo Xu, Jichuang Wang, Suhong Yu, Jingwei Shao, Bo Yuan, Lie Wang, Lee Jia*. Isolation and Characterization of Alive Circulating Tumor Cells in Patients by Immunomagnetic Negative Enrichment Coupled with Flow Cytometry. Cancer. 2015; 121(17):3036-3045.
9. Yusheng Lu, Ting Yu, Haiyan Liang, Jichuang Wang, Jingjing Xie, Jingwei Shao, Yu Gao, Suhong Yu, Shuming Chen, Lie Wang, Lee Jia*. Nitric Oxide Inhibits Hetero-adhesion of Cancer Cells to Endothelial Cells: Restraining Circulating Tumor Cells from Initiating Metastatic Cascade. Scientific Reports. 2014, 4: 4344.
10. Jingjing Xie, Yusheng Lu, Haiyan Dong, Rongli Zhao, Hongning Chen, Weiyu Shen, Patrick J. Sinko, Yewei Zhu, Jichuang Wang, Jingwei Shao, Yu Gao, Fangwei Xie, and Lee Jia*. Enhanced Specifi city in Capturing and Restraining Circulating Tumor Cells with Dual Antibody–Dendrimer Conjugates. Advanced Functional Materials. 2015; 25:1304-1313.
