个人简介

李高、博士、7003全讯论坛7003全讯白菜网址副教授

邮箱：ligao2019@mju.edu.cn

研究方向：阿尔茨海默病，β-淀粉样蛋白，化学生物学，超分子化学

教育经历

2010.09-2014.07清华大学，化学系，理学学士

2014.09-2019.07清华大学，化学系，理学博士

科研项目

1、国家自然科学基金青年项目，纳米运载机器直接清除机体内β-淀粉样蛋白的研究，22007044，主持。

2、福建省自然科学基金基础研究与高校产学合作计划面上项目，阿尔茨海默病治疗新策略，2020J01864，主持。

主要成果

[1]G. Li, J. Hu, H. Chen, Y.-X. Chen and Y.-M. Li. Cucurbit[8]uril Facilitated Michael Addition for Regioselective Cysteine Modification. Chem. Commun. 2021, 57, 6086-6089. https://doi.org/10.1039/D1CC01404H

[2]G. Li, Y. Zhou, W.-Y. Yang, C. Zhang, L. Hong and L. Jia. Inhibitory Effects of Sulfated Polysaccharides from the Sea Cucumber Cucumaria Frondosa against Aβ40 Aggregation and Cytotoxicity. ACS Chem. Neurosci. 2021, 12, 1854-1859. https://doi.org/10.1021/acschemneuro.1c00223

[3]G. Li, W. Y. Yang, W. H. Li, Y. Y. Luo, Y. J. Lim, Y. Li, A. Paul, D. Segal, L. Hong and Y. M. Li. Rational Design of a Cocktail of Inhibitors against Abeta Aggregation. Chem. Eur. J. 2020, 26, 3499-3503. https://doi.org/10.1002/chem.201905621

[4]G. Li and Y. M. Li. Truncated and Modified A beta Species in Alzheimer's Disease. Prog. Chem. 2020, 32, 14-22. https://doi.org/10.7536/Pc191212

[5]G. Li, W. Y. Yang, Y. F. Zhao, Y. X. Chen, L. Hong and Y. M. Li. Differential Modulation of the Aggregation of N-Terminal Truncated Abeta using Cucurbiturils. Chem. Eur. J. 2018, 24, 13647-13653. https://doi.org/10.1002/chem.201802655

[6]G. Li, Z. W. Hu, P. G. Chen, Z. Y. Sun, Y. X. Chen, Y. F. Zhao and Y. M. Li. Prophylactic Vaccine Based on Pyroglutamate-3 Amyloid beta Generates Strong Antibody Response and Rescues Cognitive Decline in Alzheimer's Disease Model Mice. ACS Chem. Neurosci. 2017, 8, 454-459. https://doi.org/10.1021/acschemneuro.6b00336

[7]G. Li, Y.-X. Chen and Y.-M. Li. New progress in active immunotherapy targeting to amyloid beta. Sci. China: Chem. 2015, 58, 383-389. https://doi.org/10.1007/s11426-014-5310-9