谢焕章

发布时间：2023-05-08浏览次数：587

个人简介

谢焕章，男，7003全讯白菜网址，助理研究员，主要从事药物设计、化学信息学等交叉学科研究工作。以创新药物研发为导向，针对临床上重要的药物靶标，发展药物分子设计、靶标识别、人工智能等新方法与新技术，应用于创新先导化合物发现与结构优化。

2003.9-2007.6 福建中医药大学药学专业本科

2007.9-2012.6 四川大学药物化学硕士、博士

1、科技部,国家重点研发计划,基于E级高性能计算生物医药应用软件系统研制及应用, 2017YFB0202600，参与

2、福建省中青年教师教育科研项目，海洋天然产物在线数据库的设计与开发，JAT190620，主持

3、横向课题，化学结构图像自动识别软件技术开发，主持

1. Deng, Xiaoxiao#; Xie, Huanzhang#; Lin, Min#; Liu, Huibiao; Li, Yuliang; Lu, Yusheng; Wang, Jie; Li, Yumei; Zhong, Chunlian; Xu, Huo; Jia, Lee^*; Graphdiyne oxide and graphene oxide sense monovalent cations differently: The alkyne and alkene physicochemistry, Nano Today, 2021, 38: 101141.

2. Li, Ziying; Zheng, Yilin; Shi, Huifang; Xie, Huanzhang; Yang, Ya; Zhu, Fangyin; Ke, Lingjie; Chen, Haijun; Gao, Yu^*; Convenient Tuning of the Elasticity of Self-Assembled Nano-Sized Triterpenoids to Regulate Their Biological Activities, ACS Applied Materials & Interfaces, 2021, 13(37): 44065-44078.

3. Zhang, Hui; MaoJun; Yang, Yan-Li; Liu, Chun-Tao; Shen, Chen; Zhang, Hong-Rui; Xie, Huan-Zhang; Ding, Lan; Discovery of novel tubulin inhibitors targeting taxanes site by virtual screening, molecular dynamic simulation, and biological evaluation, Journal of Cellular Biochemistry, 2021, 122(11): 1609-1624.

3. Lin, Min; Dong, Hai-Yan; Xie, Huan-Zhang; Li, Yu-Mei; Jia, Lee^*; Why do we lack a specific magic anti-COVID-19 drug? Analyses and solutions, DRUG DISCOVERY TODAY, ELSEVIER SCI LTD, THE BOULEVARD, LANGFORD LANE, KIDLINGTON, OXFORD OX5 1GB, OXON, ENGLAND, 631-636, 2021-03.

4. Zhong, Chunlian#; Yang, Jingyi#; Lu, Yusheng#; Xie, Huanzhang#; Zhai, Shengyi; Zhang, Chen; Luo, Zhiying; Chen, Xuanchen; Fang, Xuanmo; Jia, Lee^*; Achyranthes bidentata polysaccharide can safely prevent NSCLC metastasis via targeting EGFR and EMT, Signal Transduction and Targeted Therapy, 2020, 5(1): 178.

5. Zhang, Hui^*; Mao, Jun; Qi, Hua-Zhao; Xie, Huan-Zhang; Shen, Chen; Liu, Chun-Tao; Ding, Lan; Developing novel computational prediction models for assessing chemical-induced neurotoxicity using naive Bayes classifier technique, Food and Chemical Toxicology, 2020, 143: 111513.

6. Zhai, S; Deng, X; Zhang, C; Zhou, Y; Xie, H; Jiang, Z; Jia, L.; A novel UPLC/MS/MS method for rapid determination of murrayone in rat plasma and its pharmacokinetics, J Pharm Biomed Anal, 2020, 180: 113046.

7. Li, Y; Zhou, Y; Li, B; Chen, F; Shen, W; Lu, Y; Zhong, C; Zhang, C; Xie, H; Katanaev, V. L; Jia, L.; WDR74 modulates melanoma tumorigenesis and metastasis through the RPL5-MDM2-p53 pathway, Oncogene, 2020, 39(13): 2741-2755.

8. Li, Y; Chen, F; Shen, W; Li, B; Xiang, R; Qu, L; Zhang, C; Li, G; Xie, H; Katanaev, V. L; Jia, L.; WDR74 induces nuclear beta-catenin accumulation and activates Wnt-responsive genes to promote lung cancer growth and metastasis, Cancer Letters, 2020, 471: 103-115.

8. Zhou, S; Li, G. B; Huang, L. Y; Xie, H. Z; Zhao, Y. L; Chen, Y. Z; Li, L. L; Yang, S. Y.; A prediction model of drug-induced ototoxicity developed by an optimal support vector machine (SVM) method, Computers in Biology and Medicine, 2014, 51: 122-7.

10. Di-wu, L; Li, L. L; Wang, W. J; Xie, H. Z; Yang, J; Zhang, C. H; Huang, Q; Zhong, L; Feng, S; Yang, S. Y.; Identification of CK2 inhibitors with new scaffolds by a hybrid virtual screening approach based on Bayesian model; pharmacophore hypothesis and molecular docking, Journal of Molecular Graphics and Modelling, 2012, 36: 42-7.

11. Zhang, S; Cao, Z; Tian, H; Shen, G; Ma, Y; Xie, H; Liu, Y; Zhao, C; Deng, S; Yang, Y; Zheng, R; Li, W; Zhang, N; Liu, S; Wang, W; Dai, L; Shi, S; Cheng, L; Pan, Y; Feng, S; Zhao, X; Deng, H; Yang, S; Wei, Y.; SKLB1002, a novel potent inhibitor of VEGF receptor 2 signaling, inhibits angiogenesis and tumor growth in vivo, Clinical Cancer Research, 2011, 17(13): 4439-50.

12. Xie, Q. Q; Zhong, L; Pan, Y. L; Wang, X. Y; Zhou, J. P; Di-Wu, L; Huang, Q; Wang, Y. L; Yang, L. L; Xie, H. Z; Yang, S. Y.; Combined SVM-based and docking-based virtual screening for retrieving novel inhibitors of c-Met, European Journal of Medicinal Chemistry, 2011, 46(9): 3675-80.

13. Xie, H. Z; Liu, L. Y; Ren, J. X; Zhou, J. P; Zheng, R. L; Li, L. L; Yang, S. Y.; Pharmacophore modeling and hybrid virtual screening for the discovery of novel IkappaB kinase 2 (IKK2) inhibitors, Journal of Biomolecular Structure & Dynamics, 2011, 29(1): 165-79.

14. Ren, J. X; Li, L. L; Zheng, R. L; Xie, H. Z; Cao, Z. X; Feng, S; Pan, Y. L; Chen, X; Wei, Y. Q; Yang, S. Y.; Discovery of novel Pim-1 kinase inhibitors by a hierarchical multistage virtual screening approach based on SVM model, pharmacophore, and molecular docking, Journal of Chemical Information and Modeling, 2011, 51(6): 1364-75.

17. Xie, Q. Q; Xie, H. Z; Ren, J. X; Li, L. L; Yang, S. Y.; Pharmacophore modeling studies of type I and type II kinase inhibitors of Tie2, Journal of Molecular Graphics and Modelling, 2009, 27(6): 751-8.

18. Xie, H. Z; Li, L. L; Ren, J. X; Zou, J; Yang, L; Wei, Y. Q; Yang, S. Y.; Pharmacophore modeling study based on known spleen tyrosine kinase inhibitors together with virtual screening for identifying novel inhibitors, Bioorganic & Medicinal Chemistry Letters, 2009, 19(7): 1944-9.