个人简介

练殊，女，助理研究员，肿瘤转移的药理药效研究

教育经历

2010.9-2014.6   哈尔滨师范大学   化学专业   本科

2014.9-2016.6   福州大学   分析化学专业   硕士

2016.9-2020.6   福州大学   药物分析专业   博士

2019.1-2020.6   加州大学洛杉矶分校     硕博联培

主要参与的项目

1、福建省自然科学基金面上项目（CapNO干预冠状病毒侵染肺上皮细胞及快速缓解ARDS综合征的机制研究），项目编号：2021J01517，主持

2、福州市中青年教师教育科研项目（基于斯诺普利干预冠状病毒感染肺上皮细胞的机制研究），项目编号：JAT200412，主持

3、横向项目（灵芝产品在抑制肿瘤转移和促进免疫细胞功能的药物研发），2021.1-2022.2，主持。

4、国家自然青年基金项目（基于一氧化氮通过改善血液微环境干预肿瘤血路转移的分子机制研究），项目编号：81703555, 2018-2020，参与。

5、国家自然科学基金项目（循环肿瘤细胞在血管内膜的粘附和孕卵在子宫内膜的着床的相似性：预防肿瘤转移的新思路）项目编号：81773063, 2018-2021，参与。

6、国家自然科学基金面上项目（基于CRISPR/Cas9联合药物共组装仿生纳米系统用于多重靶向抗肿瘤研究），参与

主要成果

[1] Shu Lian, Yusheng Lu, Yunlong Cheng, Ting Yu, Xiaodong Xie, HaiyangLiang, YuyingYe, Lee Jia*. S-nitrosocaptopril interrupts adhesion of cancer cells to vascular endothelium by suppressing cell adhesion molecules via inhibition of the NF-кB and JAK/STAT signal pathways in endothelial cells. European Journal of Pharmacology (IF: 4.432, 二区). 2016, 791, 62-71.

[2] Shu Lian, Ruizhi Xie, Yuying Ye, Xiaodong Xie, Shuhui Li, Yusheng Lu, Bifei Li, Yunlong Cheng, Vladimir L. Katanaev, Lee Jia*. Simultaneous blocking of CD47 and PD-L1 increases innate and adaptive cancer immune responses and cytokine release. EBioMedicine (IF: 8.143, 一区). 2019, 42, 281-295.

[3] Shu Lian^#, Ruizhi Xie^#, Yuying Ye, Yusheng Lu, Yunlong Cheng, Xiaodong Xie, Shuhui Li, Lee Jia*. Dual blockage of both PD-L1 and CD47 enhances immunotherapy against circulating tumor cells. Scientific Reports (IF: 4.38, 三区). 2019, 9, 4532.

[4] Shu Lian, Xiaodong Xie, Yusheng Lu, Lee Jia*. Checkpoint CD47 function on Tumor Metastasis and immune therapy. OncoTargets and Therapy (IF: 4.147, 三区).2019, 12, 9104-9114.

[5] Ruizhi Xie^#, Shu Lian^#, Huayi Peng, Changhe OuYang, Shuhui Li, Yusheng Lu, Xuning Cao, Chen Zhang, Jianhua Xu, and Lee Jia*. Mitochondria and Nuclei Dual-Targeted Hollow Carbon Nanospheres for Cancer Chemophotodynamic Synergistic Therapy. Molecular Pharmaceutics, (IF: 4.939, 二区). 2019, 16, 2235-2248.

[6] Xiaodong Xie^# ; Shu Lian^# ; Yu Zhou; Bifei Li; Yusheng Lu; Iwin Yeung; Lee Jia* ; Tumor-derived exosomes can specifically prevent cancer metastatic organotropism, Journal of Controlled Release, (IF:9.776，一区). 2021, 331: 404-415.

[7] Yusheng Lu, Shu Lian, Yuying Ye, Ting Yu, Haiyan Liang, Yunlong Cheng, Jingjing Xie, Yewei Zhu, Xiaodong Xie, Suhong Yu, Yu Gao, Lee Jia*, S-Nitrosocaptopril prevents cancer metastasis in vivo by creating the hostile bloodstream microenvironment against circulating tumor cells. Pharmacological Research (IF: 7.658, 二区). 2019, 139, 535-549.

[8] Yusheng Lu, Shu Lian, Yunlong Cheng, Yuying Ye, Xiaodong Xie, Chengbin Fu, Chen Zhang, Yewei Zhu, M. Iqbal Parker, Lee Jia*. Circulation patterns and seed-soil compatibility factors cooperate to cause cancer organ-specific metastasis. Experimental Cell Research, (IF: 3.905, 三区). 2019, 375, 62-72.

[9] Xu-Ning Cao, Shu Lian, Honghui Ou and Xinchen Wang* Selenium Modified Carbon Nitride Nanosheets as Biomimetic catalase for Free-Radical Scavenging. 2019, Chemical communications. (IF: 6.222, 二区). 2020, 56, 916-919.

[10] 练殊^#，卢余盛^#，程云龙，谢瑞芝，李书慧，于婷，梁海燕，贾力*。斯诺普利抑制循环肿瘤细胞粘附于脐静脉内皮细胞的作用研究。药物分析，2019,01，0254-1793.